Developed and evaluated a Hemostatic Tough Adhesive (HTA) in a preclinical porcine model of solid organ injury, achieving complete hemostasis in liver and spleen wounds and outperforming leading commercial hemostatic products while maintaining biocompatibility through the healing period.

Created a bioadhesive hydrogel for sutureless dural membrane sealing, exhibiting strong adhesion in wet environments and superior mechanical performance over commercial sealants in porcine and human ex vivo models​.

Developed a simple, rapid adhesion strategy using dry chitosan polymer films to achieve instant, tough adhesion (>3,000 J/m²) between hydrogels and elastomers via non-covalent interactions, offering potential applications in tissue engineering and surgical sealing​.

Introduced swelling-triggered bioadhesive sutures that enhance wound closure by sealing puncture sites, reducing tissue stress, and enabling strong adhesion to diverse soft tissues, with applications in musculoskeletal and gastrointestinal repair​.

Developed a novel bonding strategy integrating hydrogels with biomedical plastics via physical entanglements and covalent bonding, creating strong, fatigue-resistant adhesion to reduce foreign body response in implanted medical devices.

Developed DenTAl, a tough adhesive hydrogel for intraoral drug delivery, demonstrating strong adhesion to wet oral tissues and sustained release of clobetasol-17-propionate for treating oral lichen planus and aphthous ulcers​.

Engineered a stimuli-responsive hydrogel drug delivery system that enables controlled corticosteroid release through ultrasound, temperature modulation, and nanoparticle incorporation, enhancing localized and extended drug delivery.

Developed a hydrogel-based tissue adhesive that achieves ultratough adhesion (>2000 J/m²) within minutes by leveraging topological entanglement of pH-responsive chitosan chains, enabling rapid, strong, and non-covalent bonding to wet biological tissues.

Developed biodegradable tough adhesive hydrogels with high toughness, strong adhesion, and tunable degradation, allowing controlled removal and minimal tissue damage.

Designed a dual-function hydrogel with an adhesive and gliding surface, promoting tendon healing, drug delivery, and reduced scar formation in a rat model of Achilles-tendon rupture.

Demonstrated a novel two-component bioadhesive hydrogel that provides enhanced adhesion for fetal defect repair, successfully expanding to cover spina bifida defects in a rabbit model.

Developed bioinspired mechanically active adhesive dressings that accelerate wound closure by combining strong adhesion, stretchability, and antimicrobial properties.

Designed a bioinspired tough adhesive for dynamic and wet environments, combining electrostatic interactions, covalent bonds, and energy dissipation, with applications in tissue repair and biomedical devices.